INS and diabetes mellitus: Published research documents the extensive testing under way with the “artificial pancreas,” known also as a Closed Loop System, which combines continuous glucose measurement with algorithm-driven insulin pumps to reduce hypoglycemia and improve diabetes self-care.41 The latest-generation sensors, which are more accurate and sensitive for hypoglycemia, and the development of algorithms that allow insulin infusion to be suspended during hypoglycemia and glucagon to be administered, provide a safe and effective system for persons at high risk of hypoglycemia.