Previous studies reported roles for MMP2 in regulating lung cancer invasion and vascular permeability.27, 28, 29 In the present study, exogenous overexpression and interference experiments showed that lnc‐MMP2‐2 promoted lung cancer invasion and increased vascular permeability, and that lnc‐MMP2‐2 expression was markedly higher in lung cancer tissues than in normal controls. This evidence concerns the gene MMP2 and lung cancer.