Furthermore, bioinformatics analysis indicated that lnc‐MMP2‐2 increases MMP2 expression, with these results indicating that TGF‐β mediated exosomal lnc‐MMP2‐2 might regulate lung cancer‐cell migration and invasion by promoting MMP2 expression and suggesting lnc‐MMP2‐2 as a potential diagnostic marker of lung cancer metastatic potential. This evidence concerns the gene TGFB1 and lung cancer.