This decrease was only observed at the protein level suggesting that post‐translational regulation of P‐gp may be affected as has been reported in MCF‐7 doxorubicin‐resistant cancer cell lines.54 In the IHC, the PE placenta displayed an accelerated ST maturation and loss of CT as expected,55 along with a decrease in P‐gp protein, demonstrating diffuse cytoplasmic syncytial and vasculo‐syncytial membrane staining and mirroring our observations in the floating explant model. Here, PGP is linked to cancer.