Transverse aortic constriction (TAC) in mice or rats is the most commonly used experimental method of modelling cardiac hypertrophy and fibrosis in animals.1 Currently employed treatments for patients with cardiac hypertrophy include calcium channel blockers, beta blockers, angiotensin‐converting enzyme inhibitors, angiotensin II receptor blockers, and diuretics.2, 3. Here, ACE is linked to cardiac hypertrophy.