MBOAT4 and posterior cortical atrophy: Furthermore, a multivariate model based on GOAT or PSA levels complemented with an additional panel of clinical variables measured in PCa such as age, DRE and testosterone levels demonstrated that GOAT levels could be efficiently complemented with these clinical parameters to significantly increase its accuracy for the prediction of Sig PCa, which altogether reinforce the idea that GOAT enzyme might represent a promising biomarker, complementing PSA determination for the diagnosis of Sig PCa.