Importantly, when the patients with a PSA range between 3 and 20 ng/mL (the most ambiguous region of PSA levels, which leads to a high false‐positive rate and, therefore, to a high number of unnecessary prostate biopsies) were analysed in more detail, we found that plasma GOAT, but not PSA, levels were significantly higher in patients with Sig PCa compared to the combined group of patients with negative biopsy and with non‐Sig PCa (Figure 1D). This evidence concerns the gene MBOAT4 and posterior cortical atrophy.