ALB and osteoarthritis: Additionally, a novel EP4 receptor antagonist (piprant class, grapiprant) is currently marketed to decrease inflammation and pain associated with osteoarthritis in dogs 39; this novel compound was shown to decrease paw swelling, serum sialic acid concentrations, albumin/globulin ratios, synovial inflammation and bone destruction in rodent adjuvant‐induced arthritis models 40.