This finding is in agreement with observations from some previous studies, which demonstrated a stronger inverse association between SHBG levels and risk of T2DM in women compared to men.9, 21 This inverse relationship with T2DM appears to be particularly strong in postmenopausal women.22 A 2011 meta‐analysis, however, found that higher SHBG levels were equally associated with a reduced risk of metabolic syndrome in both sexes.23 This evidence concerns the gene SHBG and type 2 diabetes mellitus.