Cancer cells have been shown to adopt an osteoblast‐like phenotype that may help them survive in the bone marrow.102 Cancer cells with an osteoblast‐like phenotype have been shown to exhibit an enhanced invasive ability.103 The dormant DTCs may be reactivated by the osteoclast‐mediated release of bone‐derived growth factors.57 The interaction between the bone marrow niche and the cancer cells was involved cancer‐derived E‐cadherin and osteogenic N‐cadherin.104. The gene discussed is CDH2; the disease is cancer.