In one study, intracardiac injection of tumour cells was performed to study late stage of metastasis.19 These DTCs may transform into more aggressive variants and grow out to overt metastasis.20 Disseminated tumour cells were found to gather in the bone marrow and display unique gene expression, including the significant enrichment of genes known to regulate interleukin‐6 (IL‐6) signalling, cell adhesion and angiogenesis. Here, IL6 is linked to neoplasm.