Deguelin has been found to cause apoptosis in several cancer cell lines.46 Our data showed that deguelin‐suppressed Bmi1 was accompanied by the increases of Noxa and cleaved caspase‐3 staining in the H1299 xenograft tumour (Figure 3E), which suggested that the induction of apoptosis was involved in deguelin‐mediated NSCLC suppression. The gene discussed is PMAIP1; the disease is cancer.