PMAIP1 and non-small cell lung carcinoma: For instance, the transcription factors c‐Myc,27 HIF‐1α,28 CREB29 and E2F130 have been described to mediate p53‐independent transcription of Noxa. Furthermore, recent studies have shown that Bmi1 suppresses Noxa expression in memory CD4 T cells and mantle cell lymphoma.11, 13 However, the mechanisms underlying Noxa induction and the functional significance of Noxa in NSCLC have not been studied.