AKT1 and cancer: It directly binds to the ATP‐binding pocket of Hsp90, interferes with Hsp90 chaperone function, decreases the expression of many Hsp90 client proteins, and induces apoptosis in cancer cells, which reduces tumour growth.53 Although deguelin has been mentioned as an Akt inhibitor,32, 34 whether Akt is a direct target of deguelin and the mechanism of how deguelin inhibits Akt activity remains undisclosed.