BMI1 and non-small cell lung carcinoma: Accumulation of evidence has demonstrated that Bmi1 plays a critical role in cancer cell invasion, metastasis, and chemoresistance.19 Overexpression of Bmi1 correlates with cancer development, progression, and therapy failure.17, 20, 21 Moreover, experimental decrease of Bmi1 protein levels results in cancer cells apoptosis and/or senescence, increasing susceptibility to cytotoxic agents and radiation therapy.22, 23 These data suggest that reducing Bmi1 protein level may have a beneficial effect in multiple types of cancer including NSCLC.