FSTL5 overexpression remarkably decreased tumor volume and weight of SMMC7721 cell xenografts by 53.1% and 46%, respectively; tumor volume: control: 1357 ± 434.9 mm3 vs FSTL5: 636.6 ± 102.7 mm3; and tumor weight: control: 0.815 ± 0.104 g vs FSTL5: 0.44 ± 0.04 g) (Figure 7C and D). The gene discussed is FSTL5; the disease is neoplasm.