TRPV4 and ischemia: The neuroprotective role of TRPV4 in ischemia episodes has been highlighted recently, because TRPV4 is involved in cerebral ischemic–reperfusion injury and recovery of brain edema.33,34 Stimulation of TRPV4 is observed to be cytotoxic per se for cultured cortical neurons, as expected since the activation of TRPV4 is known to induce cytotoxicity in many types of cells.34–37