Sex steroids exert potent feedback on GnRH neuron activity (Pielecka et al., 2006; Moenter et al., 2009), and altered serum sex steroid levels were reported in other rodent models of epilepsy (Amado et al., 1987; Amado and Cavalheiro, 1998; Edwards et al., 2000; Scharfman et al., 2008). Here, GNRH1 is linked to epilepsy.