SLE patients had lower proportions of Tregs that were “single CD25-positive” [−1.428, (−1.982, −0.873), p < 0.001, I2 = 93.4%] and “CD127-negative” [−1.093, (−2.002, −0.183), p = 0.018, I2 = 92.6%] compared to controls. The gene discussed is IL7R; the disease is systemic lupus erythematosus.