Finally, the other eight groups that used “CD127-negative” to define Tregs showed that such cell numbers decreased in SLE patients [−1.093, (−2.002, −0.183), p = 0.018] with statistical heterogeneity (I2 = 92.6%, p < 0.001) and publication bias (t = −3.05, p = 0.022). This evidence concerns the gene IL7R and systemic lupus erythematosus.