Interestingly, both father and brother, exhibiting aortic root dilatation, and sister of proband, in whom upper range of normal aortic root dimensions were observed, showed TGFBR3 mutation, thus suggesting a cosegregation of TGFBR3 variant with the presence of aortic root dilatation. The gene discussed is TGFBR3; the disease is Aortic root aneurysm.