MTHFR and hypertensive disorder: Beyond these rare genetic variants, other polymorphisms identified in the proband such as MTHFR p.Ala222Val (heterozygous) associated with severe cardiovascular manifestations in MFS patients or abdominal aortic aneurysm [46–48] or NOS3 p.Glu298Asp (heterozygous) associated with hypertension [49] and abdominal aortic aneurysm [50] could interact to modulate the clinical phenotype.