Decreased nephrin phosphorylation caused by phosphatases were also observed in various models (53), such as protein tyrosine phosphatase 1B (PTP1B) in rat with puromycin aminonucleoside nephrosis (PAN) (54) and Src homology region 2 domain-containing phosphatase-1 (SHP-1) in human podocytes with hyperglycemia (55). This evidence concerns the gene NPHS1 and Hyperglycemia.