NPHS2 and nephrotic syndrome: Other types of nephrotic syndrome (NS), including familial and sporadic steroid resistant nephrotic syndrome (SRNS) (28–40% and 6–19%, respectively) (90, 91, 104–107), adult-onset FSGS (108–110), and non-diabetic ESKD in African Americans (111) have also found to exhibit NPHS2 mutations.