NPHS1 and diabetic kidney disease: Downregulation of nephrin has been observed in many human glomerular diseases by detecting protein and mRNA levels, such as minimal change disease (76), membranous nephropathy, membranoproliferative glomerulonephritis, IgA nephropathy, lupus nephritis (77), diabetic kidney disease (DKD) (78, 79), and preeclampsia (80).