PFKFB3 and neoplasm: Lowering glycolysis by low dose pharmacological PFKFB3 inhibition using 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) or endothelial PFKFB3 haplodeficiency did not affect tumor growth but normalized tumor vessels leading to lower cancer cell invasion, intravasation and metastasis (Cantelmo et al., 2016).