VEGFA and neoplasm: Also, recent single cell data obtained from TECs isolated from tumors treated with anti-DLL4 (which inhibits Notch signaling and results in an increased, non-functional vasculature) and/or VEGF inhibition (which reduces tumor vessel density) showed that glycolytic genes were amongst the most activated ones in tip cell-like TECs upon both anti-angiogenic treatments (Zhao et al., 2018).