Lowering glycolysis by low dose pharmacological PFKFB3 inhibition using 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) or endothelial PFKFB3 haplodeficiency did not affect tumor growth but normalized tumor vessels leading to lower cancer cell invasion, intravasation and metastasis (Cantelmo et al., 2016). The gene discussed is PFKFB3; the disease is cancer.