MDM2 and neoplasm: The measuring criteria for that were the reduction in the growth pattern of a tumor, increased cytotoxicity for tumor cells, and increment in survival rate. More importantly, the pharmacokinetics profile of RG7112 MDM-2 inhibitor in mice supported the fact that it can easily cross the blood-brain barrier, as most of the MDM-2 antagonist experimented previously were unable to cross the blood-brain barrier [2].