The dual role of mdig in breast cancer was supported by an earlier observation showing that the oncogene c-myc, a possible transcriptional regulator for mdig,2 can be both oncogenic for cancer cell proliferation and suppressive for cancer cell motility, invasion and metastasis,31 In human neuroblastoma, Schwab et al.32 also provided evidence showing that N-myc, a myc family member, may play an important role in tumor regression, leading to favorable outcomes for some later stage neuroblastomas. Here, RIOX2 is linked to breast cancer.