RIOX2 and neoplasm: Histone modifications play crucial roles in organizing the nuclear architecture and regulating the transcription of several genes implicated in breast carcinogenesis.19 Prompted by the observation that reduced mdig expression enhances the chromatin accessibility of genes implicated in metastasis, we queried the expression status of mdig, as well as levels of the heterochromatin marker H3K9me3, in breast cancer patients.