G. Don, was reported to have a potent antigastric cancer activity both in vitro and in vivo via antiproliferation of G0/G1 arrest and cell proapoptosis, including PI3K/Akt pathway, ERK activity, stimulated cytochrome C release, and caspase 3/7 activity accompanied with an increase of Bax/Bcl-2 ratio [31]. Here, CASP3 is linked to cancer.