In the comparison between the AERD group vs. asthma, we detected 14 SNPs associated with risk in 9 genes (ACE, FSIP, TBXAS1, IL10, IL1B, CYP2C19, ANX4, TBXAS1, and IL13), and 5 SNPs associated with protection in 4 genes (IL10, PTGER2, OBSCN, and PPARG). The gene discussed is ANXA4; the disease is asthma.