High PD-L1 was found to be obviously correlated with positive liver cirrhosis (OR = 1.66, 95% CI: 1.10-2.50, P = 0.02; Figure 3A), positive portal invasion (OR = 1.96, 95% CI: 1.04-3.68, P = 0.04; Figure 3B) and poorer tumor Barcelona Clinical Liver Cancer (BCLC) stage (OR = 0.30, 95% CI: 0.10-0.88, P = 0.03; Figure 3C). The gene discussed is CD274; the disease is liver cancer.