On a systemic level (plasma) 12 h post-infection IL-6, IL-10, and MCP-1 was higher in TFPI-2−/− mice and no significant changes were observed in INF-γ, TNFα, and IL-12p70 (Figure 6C), whereas in BALF fluid, IL-10, and MCP-1 was higher in TFPI-2−/− mice. This evidence concerns the gene TNF and infection.