In a 12-years follow-up examination of a Japanese population in the town of Hisayama, from December 1988 through to November 2000, Wakugawa et al. (49) demonstrated that elevation of serum CRP levels was an independent risk factor for future ischemic stroke in men, whereas no association between serum CRP levels and the risk of future hemorrhagic stroke in either sex was observed. This evidence concerns the gene CRP and ischemic stroke.