Moreover, high-energy demanding cancer related process are strictly related to the cross-talk between tumor cells and some key players of the tumor microenvironment (TME), such as macrophages (TAM, tumor-associated macrophage), that in turn, fuels cancer progression through the formation of an inflammatory milieu characterized by the production of different cytokines such as IL-1, IL-6, and IL-8 among others. This evidence concerns the gene IL1B and neoplasm.