In several cancer cells, the expression and the activity of ERRα, together with its cofactors (PGC-1 α/β), is further influenced by oncogenic signals (IGF1-/IGF1R pathway, estrogen signaling, Wnt/β-cat/TCF, mTOR pathway) (Figure 1A) and can thus be re-directed to induce metabolic programs (Figure 1B) favoring tumor growth and progression. The gene discussed is HNF4A; the disease is neoplasm.