AD mouse models on complement 32, colony stimulating factor 1 receptor3,4, inflammasome Nod-like receptor protein 3 (Nlrp3)5, Caspase-1 (Casp1)5, scavenger receptor class B type I6, poly(ADP-ribose) polymerase 17, or complement 1qa8 null background, show improvements in cognitive behaviour, synaptic pathology, and often amyloid beta peptide (Aβ) pathology. The gene discussed is CASP1; the disease is Alzheimer disease.