The oncogenic JAK2 mutant (V617F) found in myeloproliferative neoplasm (MPNs) is associated with increased DNA damage and replication stress58,59; however, JAK2V617F+ MPN patients typically remain clinically and cytogenetically stable over decades60, perhaps through upregulation of RECQL561. The gene discussed is JAK2; the disease is myeloproliferative neoplasm.