In both PNT and PCa tissue, AR expression is significantly higher in epithelium then in stroma (Sign test: p < 0.001 for both, Fig. 4A,B), whereas ER expression is significantly lower in epithelium in both PNT and PCa tissue (Sign test: p < 0.001 for both, Fig. 4C,D). The gene discussed is ESR1; the disease is posterior cortical atrophy.