The allele showing the strongest association trend within DQB1*06 group is HLA-DQB1*0603, part of the HLA class II haplotype HLA-DRB1*1301–HLA-DQA1*0103–HLA-DQB1*0603 (in tight LD in Europeans, r2 > 0.9) and associated with head and neck14 and cervical cancer15, both squamous cell carcinomas linked to HPV infection. This evidence concerns the gene HLA-DRB1 and squamous cell carcinoma.