HLA-DRB1 and Alzheimer disease: In Asians, the most relevant amino acid positions for AD risk were Ala-104 and Glu-98 (in tight LD, r2 = 1) in HLA-DRB1 and Leu-23 in HLA-DQB1 (Supplementary Table 5); their individual models fitted the data as well as HLA-DRB1*0701 and HLA-DQB1*0401 alleles (Supplementary Table 5).