RUNX1 and neoplasm: Cellular localisation is critical to the function of YAP, with pathway inhibition allowing unrestricted translocation of YAP to the nucleus therefore permitting YAP to bind with various transcription factors such as tumour proteins p63/p73, runt-related transcription factor 1/2 (Runx1/2), octamer-binding transcription factor 4 (OCT4) and the most favoured interaction, the TEA domain (TEAD) family15–17.