Consistent with the apoptotic cell death observed in vitro, genetic ablation of Ripk3 in Hoil-1E-KO or the loss of Mlkl in HoipE-KO mice failed to prevent aberrant cell death and skin inflammation and did not delay the postnatal lethality (Fig. 6b, c, e and Supplementary Fig. 5). The gene discussed is RIPK3; the disease is dermatitis.