TNFRSF1A and skin disorder: Since aberrantly increased cell death was the first abnormal event we could detect in the epidermis of HoipE-KO and Hoil-1E-KO mice and because it is also observed in the absence of TNFR1 in adult mice, we next evaluated genetically whether and, if so, which form(s) of aberrant cell death cause the early and the late dermatitis.