Strikingly, pharmacologic inhibition of the kinase activity of RIPK1 rescued the majority of Tnfr1KO;Hoil-1E-KO mice from dermatitis for the duration of the treatment with only three of the ten treated mice developing small punctate scales (Fig. 7c–e and Supplementary Fig. 7c). The gene discussed is RIPK1; the disease is dermatitis.