MLKL and skin disorder: Ripk3KO;Casp8KO;Hoil-1E-KO mice survived without developing any signs of skin inflammation well beyond the 70-day time point at which the Tnfr1KO; Hoil-1E-KO mice succumb to severe dermatitis (Fig. 6e), although they had to be sacrificed at later times because of lymphadenopathy and splenomegaly (Supplementary Fig. 6h) caused by the combined deficiency in caspase-8 and RIPK3 or MLKL, as previously reported10,38,40.