At the end of 8 weeks, this difference was intensified (Fig. 1D and E) and the HF-diet was able in worsening fasting serum glucose (Fig. 1F) and insulin tolerance (Fig. 1G) by decrease the constant of glucose decay (Fig. 1H) when compared to the CT group (P < 0.05). The gene discussed is INS; the disease is hydrops fetalis.