In the previous study of AdipoR1 KO-induced retinal degeneration it was shown that the KO mice had developed a flecked retina, an accumulation of subretinal macrophages/microglia, highly diminished electroretinograms (ERGs) prior to significant photoreceptor loss, and a severe preferential deficiency of docosahexaenoic acid (DHA) in the eye5. This evidence concerns the gene ADIPOR1 and retinal degeneration.