Lastly, we profiled gene expression between AdipoR1 WT, heterozygous (HET), and KO animals and found that the interphotoreceptor retinoid-binding protein (IRBP, aka RBP3) was strongly upregulated in KO eyes prior to retinal degeneration, suggesting retinoid metabolism dysfunction. The gene discussed is RBP3; the disease is retinal degeneration.