ADIPOQ and Insulin resistance: It has been reported that adiponectin acts through binding to its receptors, adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2), respectively1,2, and this relationship has been further propagated by studies that have shown that ablation of AdipoR1/AdipoR2 in mice led to the induction of insulin resistance and glucose intolerance3.