Several such DEGs are related to beta-amyloid and AD, including Ttr—encoding transthyretin which is an amyloid beta scavenger45, mt-Rnr2—encoding the mitochondria factor humanin46 which is protective against AD, Itm2b—an inhibitor of beta-amyloid deposition47, and Apba2 (Mint2)—a stabilizer of amyloid precursor protein APP48. Here, ITM2B is linked to Alzheimer disease.