TPX2 and Alzheimer disease: Among the T4 DEGs, 121 were also altered by mTBI (Fig. 9f) and T4 reversed the TBI-induced changes of 93 genes (Fig. 9g), including Ttr, Wdr72 (implicated in cognitive processing speed53), and Tpx2 (protective of neurocyte apoptosis in an AD model54) (Fig. 9h).