Splicing of INSR and MAP3K4 in samples from DM1 individuals who had preserved ankle strength showed intermediate changes between DM1 individuals who had ankle weakness and UA controls, while splicing patterns of MBNL2, MBNL1, and CLASP1 appeared similar in DM1 individuals regardless of ankle strength (Fig. 9c, d). The gene discussed is MBNL1; the disease is myotonic dystrophy type 1.