MAP3K4 and myotonic dystrophy type 1: Inclusion of MBNL2 exon 6, MBNL1 exon 7, and CLASP1 exon 20 in DM2 urine exRNA samples was significantly different than in the UA and DM1 groups, showing an intermediate change, while the splicing pattern of INSR and MAP3K4 appeared similar in the DM2 and UA groups (Fig. 5d, f).