EHF is associated with fibrosis in NAFLD and is upregulated in both datasets; however, other genes associated with advanced fibrosis including CXCL6, STMN2, UBD and DKK3 are upregulated in the clinical study but downregulated in our model, highlighting that our hiPSC-Hep cell system, which lacks the presence of other cell types such as stellate cells, is modeling the early steatosis stage but not advanced fibrosis, as expected. This evidence concerns the gene DKK3 and metabolic dysfunction-associated steatotic liver disease.