Also, improvement of hepatic steatosis by CD36 downregulation in a murine model of NAFLD was reported for another FXR agonist, GW4064 (Ma et al., 2013), which is also an inhibitor in our phenotypic model, with similar potency to OCA, albeit lower efficacy (data not shown). Here, CD36 is linked to metabolic dysfunction-associated steatotic liver disease.