So, we hypothesized that two isoforms of MMP2 can be important mediators in diabetic injury and the current study was designed to expand on these initial observations and to determine if differences exist between the spatial and temporal patterns of MMP-2 isoform expression in murine models of Type 1 (streptozotocin) and Type 2 (db/db mice) diabetic nephropathy. Here, MMP2 is linked to diabetic kidney disease.