Finally, HLA-B*51 was harboured in two HLA-B-HLA-DR distinct haplotypes: B*51-DR*11 in 14/26 (53.8%) of HLA-B*51 positive BD patients and in 14/37 (37.8%) of HLA-B*51 positive HC (p = 0.231); and B*51-DR*4 in 1/26 (3.8%) of HLA-B*51 positive BD patients and in 14/37 (37.8%) of HLA-B*51 positive HC (p = 0.013; pc = 0.065 OR 0.06 95%CI 0.01–0.54) according to, but not fully confirming, the previous observation of a lack of association between B*51-DR*4 and BD susceptibility in Sardinians (13). Here, HLA-B is linked to Behcet disease.