Professional athletes experience moreupper respiratory tract infections (URTI) than recreationalathletes, with 30–70% ofillness episodes havingidentifiable pathogensassociated, of these bacterial infections represent a fraction [24].The most important result of this study is the high similarity of the tested G- LPS bearing bacteria as evident through IgG reactivity, and the dissonance in formation of IgG with IgA to probiotic strains, versus accordance for opportunistic pathogens in professional athletes, as well as the confirmation of IgG2 being the primary bacteria specific IgG subclass. The gene discussed is CD79A; the disease is Respiratory tract infection.