It involves melanogenesis regulation and induces the downstream expression of the nuclear receptor subfamily 4 group A member 2 gene (NR4A2), which is a transcription factor primarily expressed in the central nervous system, including dopaminergic neurons related to PD pathogenesis and is essential for dopaminergic phenotype induction and late dopaminergic precursor neuron survival (Garcia‐Borron et al., 2014; Saucedo‐Cardenas et al., 1998; Tell‐Marti et al., 2015). Here, NR4A2 is linked to Parkinson disease.