Free insulin levels at the end of clamp were similar between the hypoglycemia (968.5 ± 149.1 pmol/L) and euglycemia groups (1025.4 ± 81.4 pmol/L, P = 0.996) but significantly higher (P < 0.001) than those in the sham-saline (31.3 ± 6.3 pmol/L) group (Fig. 1c). Here, INS is linked to Hypoglycemia.