We analysed 2634 C9orf72-negative patients with ALS, FTD or FTD-ALS (Supplementary Table 2), and found a significant association between rs9357140 genotypes and age of onset (adjusted P = 0.007 for recessive model) (Supplementary Table 2). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.