C9orf72 and amyotrophic lateral sclerosis: To evaluate if rs9357140 genotypes modify disease phenotypes, we performed a trend analysis using the Cochran–Armitage test to analyse the association between rs9357140 genotypes and C9orf72 disease phenotypes (ALS versus FTD, ALS versus FTD-ALS, or FTD versus FTD-ALS) under an additive model (AA versus AG versus GG) (Supplementary Table 8); and found no statistically significant results (P > 0.05).