TSBP1 and early-onset autosomal dominant Alzheimer disease: Our survey of the literature and the GWAS catalogue database (https://www.ebi.ac.uk/gwas/) revealed that SNPs within or close to the C6orf10/LOC101929163 locus (Supplementary Fig. 8) are associated with autoimmune disorders (multiple sclerosis, rheumatoid arthritis, systemic sclerosis, Grave’s disease and asthma), as well as neurodegenerative diseases (FTD, Parkinson’s disease and Alzheimer’s disease) (Lambert et al., 2013; Ferrari et al., 2014; Lu et al., 2017), highlighting the role of the immune system in neurodegeneration (Supplementary Table 11).