Recent studies about leukemic transformation in MPNs show ASXL1,SRSF2,IDH1,IDH2,RUNX1 mutations have been associated with leukemic transformation in PMF, whereas SRSF2,IDH2 mutations in PV and TP53,EZH2 mutations in ET predicts more leukemic transformation (92). The gene discussed is EZH2; the disease is acquired polycythemia vera.