Although somatic TP53 mutations are frequently seen in 50% of solid tumors, they are uncommon in de novo AML (5% to 18%) and they are associated with secondary or therapy-related AMLs. TP53 mutations often coexist with complex karyotypes, chemotherapy resistance, and reduced overall survival compared with TP53 wild AML patients. This evidence concerns the gene TP53 and acute myeloid leukemia.