Several cofactors, such as coactivators steroid receptor coactivator 1 (SRC1), transcriptional mediators/intermediary factor 2, SRC3 and corepressors nuclear receptor-interacting protein 1, nuclear receptor subfamily 0 group B member 1, are actively involved in the regulation of AR-mediated transcription, and might play an important role in AIS etiopathogenesis (12,13,14,15). This evidence concerns the gene AR and androgen insensitivity syndrome.