In the report by Stoffel and coworkers (2018) gathering 430 patients diagnosed with CRC before 50 years of age, the corresponding yield was 10.7% for LS and 4.6% for known non-LS hereditary CRC conditions (i.e., mutations in APC, MUTYH, and SMAD4). This evidence concerns the gene SMAD4 and colorectal carcinoma.