LGR5 and obesity due to melanocortin 4 receptor deficiency: In addition, the stem cell markers like leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5), olfactomedin 4 (Olfm4), and BMI1 (protooncogene, polycomb ring finger) expression increased in the Lepob/ob intestine as well as their organoids (Figures 2(f) and 2(i)), suggesting that obesity-associated gut microbiome dysbiosis exposure is associated with faster/abnormal cellular turnover of intestinal cells, along with increased stemness [15].