The intestine being a highly regenerating organ, where intestinal epithelia rejuvenate every 3–7 days, we hypothesize that obesity-induced gut microbiome dysbiosis may be associated with the abnormalities in cellular turnover (i.e., cell death versus survival/proliferation) that impact gut permeability via modulation of tight junction and mucin formation. The gene discussed is MUC5AC; the disease is obesity due to melanocortin 4 receptor deficiency.