In an preclinical study using the polyoma middle T oncoprotein breast cancer and the Rip1-Tag2 pancreatic neuroendocrine tumor mouse models it was shown that anti-angiogenic therapy can improve anti-PD-L1 treatment and further, the other way round that anti-PD-L1 therapy can sensitize tumors to anti-angiogenic therapy and prolong its efficacy (74). The gene discussed is CD274; the disease is breast cancer.