As the induced FasL expression in tumor endothelial cells which acquired the ability to kill effector CD8(+) T-cells but not regulatory T-cells was mediated by tumor-derived VEGF, IL10 and prostaglandin E2 cooperatively, the authors proposed a “tumor endothelial death barrier” that contributes to the tumors immune escape cells (76). This evidence concerns the gene CD8A and neoplasm.