Angiogenic growth factors were further shown to suppress the expression of adhesion molecules involved in leukocyte binding (e.g., ICAM-1/2, VCAM-1, E-selectin and CD34) in tumor endothelial cells, which then causes the unresponsiveness of tumor endothelial cells to inflammatory signals, a phenomenon called endothelial cell anergy that causes lymphocyte tolerance (45–48). This evidence concerns the gene ICAM1 and neoplasm.