CD8A and neoplasm: In addition, to tumor endothelial cell anergy that limits the adhesion and subsequent extravasation of recruited leukocytes, tumor-derived factors can further induce endothelial cell-mediated apoptosis of recruited immune cells, e.g., by induced death mediator Fas ligand (FasL, also called CD95L) expression which directly kills anti-tumor T-cells finally leading to an inefficient recruitment of effector CD8(+) T-cells into the tumor (12, 75).