CTLA4 and cancer: Although the use of monoclonal antibodies directed against cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and the programmed cell death-1 (PD-1/CD279) T-cell receptor and/or its ligand (programmed death-ligand 1 (PD-L1/B7-H1/CD274) showed unprecedented durable responses in some patients with a variety of cancers, acquired resistance to immune checkpoint antibody blockades was commonly observed in most cancer patients (59, 60).