TGFB1 and neoplasm: Once cells overcome the cytostatic and apoptotic effects of TGF-β, this cytokine regulates cell plasticity, a fact that has been elegantly evidenced in a study by Coulouarn and col., where they proposed different liver TGF-β gene signatures, defining a cohort of genes related to its tumor suppressor capacity and another cohort of genes related with its tumor promoting effects: the early and the late TGF-β-signatures.