Transgenic rats that express a mutated form of the CCL2 (acting as a negative-mutant), and tail vein injection of adenovirus that overexpress a truncated form of TGF-β receptor II (acting as a negative-receptor mutant) attenuate liver fibrosis in a DEN-induced fibrosis model in rats (49), suggesting the relevance of inflammation and TGF-β pathway during this disease. The gene discussed is TGFB1; the disease is Hepatic fibrosis.