Of major importance, these primary events (i) are observed in almost 100% of precursor MM cells; (ii) are associated to overexpression of Cyclin D (1, 2, or 3) and Myc in precursor MM cells; (iii) are stable with time and (iv) are correlated with some presenting features and clinical outcome, making MM as many and multiple (they are different species of MM, see below). The gene discussed is MYC; the disease is Miyoshi myopathy.