To further confirm the promoting role of HIF-1α in lung cancer, we have developed a mouse with overexpression of HIF-1α in the airway epithelium by crossing a CCSP-rtTA mouse to HIF-1α Tg mouse (CCSP-rtTA/HIF-1α Tg mouse) (Figure 4A, 4B). Here, SCGB1A1 is linked to lung carcinoma.