AML cells treated with rapamycin or AICAR show increase in number of apoptotic cells, which is dose dependent with maximum of 3-fold with AICAR (10mM) and 2 fold with rapamycin (20nM) compared to non-treated cells measured by annexin V assay (Figure 1A & 1B). This evidence concerns the gene ANXA5 and acute myeloid leukemia.